Primary aldosteronism with concurrent primary hyperparathyroidism: clinical case load in a single centre

A. Concistré, L. Petramala, L. Zinnamosca, A. Settevendemmie, F. Corpaci, C. Marinelli, G.F. Tonnarini, G. D’Ermo, G. De Toma, C. Letizia

Secondary Hypertension Unit, Department of Internal Medicine and Medical Specialties and Department of Surgery “P. Valdoni”, University of Rome “La Sapienza”, Rome, Italy.claudio.letizia@uniroma1.it

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• Endocrinology

OBJECTIVE: Primary aldosteronism (PA) represents the main cause of endocrine secondary arterial hypertension in which aldosterone production is inappropriately elevated. Primary hyperparathyroidism (PHPT) is an endocrine disease characterized by hypercalcemia due to overproduction of parathyroid hormone (PTH). Although these two endocrine pathologies are secondary to hypertension in middle aged population, the occurrence of the PHPT in PA patients has rarely reported in the literature. The aim of the study was to describe some PA patients with concurrent PHPT, referred in a tertiary center of arterial hypertension.

PATIENTS: We performed a retrospective study. In particular, the registry of 306 patients with PA seen in our center since 2004 was examined and revealed 8 patients (2.6%) with concurrent PHPT.

CONCLUSIONS: There are several possible explanations for the association of these two endocrine disorders, including the combination was a random finding that PA inheres PHPT or vice versa.

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