Protective role of Pleurotus porrigens (Angel’s wings) against gentamicin-induced nephrotoxicty in mice

A. Hajizadeh Moghaddam 1, M. Javaheri 1, S.F. Natavi 2, M.R. Mahdavi 3, S.M. Nabavi 1,2, M.A. Ebrahimzadeh 2

1 Department of Biology, University of Mazandaran, Babolsar (Iran) 2 Pharmaceutical Sciences Research Center, School of Pharmacy and Traditional and Complementary Medicine Research Center; and 3 Faculty of Paramedical Sciences, Mazandaran University of Medical Sciences, Sari (Iran)

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• Pharmacology

Abstract. – Objectives: This study was conducted to quantitatively evaluate the recovery effects of methanolic fraction Angel’s wings on gentamicin (GM)-induced nephrotoxicity.
Material and Methods: Renal injury was achieved by injecting 100 mg/kg, intraperitoneally of GM in normal saline. Extract were administrated intraperitoneally at doses 200 and 400 mg/kg. Blood samples were examined for serum creatinine, serum urea, and blood urea nitrogen after the 10 consecutive days of treatment.
Results: Results show that GM-induced nephrotoxic animal model was successfully prepared. Methanolic fraction of Angel’s wings attenuated the gentamicin-induced increase in level of serum creatinine, serum urea, and blood urea nitrogen.
Conclusions: The present study shows that the extract at the doses 200 and 400 mg/kg, intraperitoneally offered significant nephroprotective action that is comparable with control group.

Corresponding Author: Mohammad Ali Ebrahimzadeh, Ph.D; e-mail: zadeh20@yahoo.com

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