Eur Rev Med Pharmacol Sci 2015; 19 (3): 517-519

Limb deformity in a newborn. Is rifampicin just an innocent bystander?

T. Kalayci, T. Erener-Ercan, G. Buyukkale, M. Cetinkaya

Department of Pediatrics, Department of Neonatology, Ministry of Health, Kanuni Sultan Suleyman Teaching and Research Hospital, Istanbul, Turkey. tugbaerener@yahoo.com

OBJECTIVE: The first-line antituberculous agents for use during pregnancy have minimal teratogenic effects. The possibility of limb deformity during rifampin use, however, was reported by some researchers.

CASE REPORT: A male newborn was born with a hypoplastic right forearm to a mother with tuberculosis who used isoniazid and rifampicin in the first two months of her pregnancy.

CONCLUSIONS: The limb anomaly in our case might be attributed to rifampicin usage during the first 2 months of pregnancy. Caution should be given with regard to possible congenital malformations which could be associated with the treatment of pregnant women with antituberculous drugs.

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To cite this article

T. Kalayci, T. Erener-Ercan, G. Buyukkale, M. Cetinkaya
Limb deformity in a newborn. Is rifampicin just an innocent bystander?

Eur Rev Med Pharmacol Sci
Year: 2015
Vol. 19 - N. 3
Pages: 517-519

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