Beneficial effects of Flavonoids after ambulatory therapy with Combined Hemorrhoidal Radiocoagulation (CHR)

V. Filingeri, D. Sforza

Department of Experimental Medicine and Surgery, University “Tor Vergata”, Rome, Italy. v.filingeri@tiscali.it

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• Pharmacology

BACKGROUND: Phlebotropic activity, protective effect on the capillaries and anti-inflammatory properties of the Flavonoids have been reported in literature. Recently, we evaluated the effect of these drugs in controlling postoperative symptoms of proctologic surgery. In this randomized study we compared the results obtained in two groups of patients, with grade II haemorrhoids, submitted to radiofrequency coagulation of the hemorrhoidal nodule with radiofrequency scalpel (CHR), to verify the effects of Flavonoids to reduce further symptoms after treatment.

PATIENTS AND METHODS: Out of 70 patients initially randomized, a total of 59 patients regularly returned to outpatient visit at least for 1 month of follow-up. Consequently, two groups of patients were considered: Group A, represented by 28 individuals treated with Flavonoids, and Group B, consisting of 31 patients as a control group. Our purpose was to determine: grade of pain after procedure and at first evacuation (score from 1 to 10), bleeding, incidence of failures and complications, patient’s satisfaction after 30 days from the treatment (score from 1 to 10).

RESULTS: We observed that the results obtained regarding the pain reported at the end of procedures (2.51 ± 1.4 for group A and 2.54 ± 1.15 for group B) and at the first evacuation (2.6 ±.1.52 for group A and 2.7 ± 1.18 for group B) are similar in both study groups. Instead, the mean score on overall satisfaction at 30 days from the treatment showed a statistical significance (8.32 ± 1.72 for group A and 6.64 ± 1.78 for group B; p < 0.05). There were no reported other important issues.

CONCLUSIONS: Our results confirm the usefulness of Flavonoids to make more comfortable the post-treatment period.

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