Cefixime for the prophylaxis of urinary tract infections in children with malformative uropathies: an open study

G. Stranieri, S. Zampogna*, V. Ielapi**, R.G. Defilippo@, V. Defilippo$, G. Cristofaro#, R. Galiano§, S. Capillo, L. Madonna, S. Cifalà‡, V. Ferro&, R. Rubino

Struttura Complessa di Chirurgia Pediatrica, Azienda Ospedaliera “Pugliese Ciaccio” – Catanzaro (Italy)
* Struttura Complessa di Pediatria, Azienda Ospedaliera “Pugliese Ciaccio” – Catanzaro (Italy)
** Struttura Complessa di Urologia, Azienda Ospedaliera “Pugliese Ciaccio” – Catanzaro (Italy)
@ Facoltà di Farmacia – Università di Messina (Italy)
$ Facoltà di Farmacia – C.T.F. – Università di Messina (Italy)
# Facoltà di Farmacia – Università “Magna Graecia” – Catanzaro (Italy)
§ Struttura Complessa di Patologia Neonatale, Azienda Ospedaliera “Pugliese Ciaccio” – Catanzaro (Italy)
& Struttura Complessa di Chirurgia, Azienda Ospedaliera “Pugliese Ciaccio” – Catanzaro (Italy)

---

• Pediatrics

Abstract. – Urinary tract infections are often associated with urinary anomalies. An appropriate pharmacologic treatment may prevent, or may at least limit, any kidney damage due to pyelonephritis. The antibiotic prophylaxis plays a role as significant as early surgical therapy, taking into consideration also the present limitative trend for a softer therapeutic regimen. In the past few years a greater bacterial resistance has emerged against some commonly administered antibiotics. Cefixime (3rd generation cephalosporin) has been used on a wide series of patients suffering from urinary infections associated with urinary tract anomalies. A few significative results emerge from the present study. In conclusion, cefixime’s effectiveness long-term prophylaxis of urinary infections associated with anomalies.

Free PDF Download