Eur Rev Med Pharmacol Sci 2010; 14 (6): 513-520

Efficient “one-pot” synthesis of novel 3-azabicyclic spiro-1’,2’,4’-triazolidin-3’-thiones catalyzed by potassium superoxide and their in vitro antibacterial and antifungal activities

V. Kanagarajan, M. Gopalakrishnan

Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University, Tamil Nadu (India)

Abstract. – A new series of novel 3-azabicyclic spiro 1’,2’,4’-triazolidin-3’-thiones 15-21 catalyzed by potassium superoxide under microwave irradiation have been synthesized and studied for their in vitro microbiological evaluation on clinically isolated bacterial strains namely Micrococcus luteus, Bacillus subtilis, Bacillus cereus, Pseudomonas aeuroginosa and fungal strains namely Aspergillus niger, Candida albicans, Candida 6 and Candida 51. Results of the in vitro microbiological evaluation of the synthesized compounds are discussed.

Corresponding Author: Mannathusamy Gopalakrishnan, PhD; e-mail: profmgk@yahoo.co.in

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To cite this article

V. Kanagarajan, M. Gopalakrishnan
Efficient “one-pot” synthesis of novel 3-azabicyclic spiro-1’,2’,4’-triazolidin-3’-thiones catalyzed by potassium superoxide and their in vitro antibacterial and antifungal activities

Eur Rev Med Pharmacol Sci
Year: 2010
Vol. 14 - N. 6
Pages: 513-520

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