Pancreatic b-cell is responsible for insulin secretion in response to the availability of nutrients. Type 2 diabetes mellitus (T2D) is the result of pancreatic b-cell failure to supply sufficient amount of insulin accompanied with decreased sensitivity of the body tissues to respond to insulin. The insulin secretion apparatus of b-cell is uniquely equipped with multiple … Continue reading Metabolic signaling of insulin secretion by pancreatic β-cell and its derangement in type 2 diabetes