Expression features of CXCR5 and its ligand, CXCL13 associated with poor prognosis of advanced colorectal cancer
X.-W. Qi, S.-H. Xia, Y. Yin, L.-F. Jin, Y. Pu, D. Hua, H.-R. Wu Department of General Surgery, the Second Affiliated Hospital of Soochow University, Suzhou, China. haorongwusdfey@163.com
OBJECTIVE: CXCL13 plays a unique role in the trafficking and homing of B1 cells associated with its cognate receptor, CXCR5. The CXCR5-CXCL13 axis has been previously demonstrated to be a poor prognosis factor in malignancies. However, the clinical significance of the CXCR5-CXCL13 expression in colorectal cancer carcinoma (CRC) remains unclear. The aim of this study was to investigate the CXCR5-CXCL13 expression in CRC and determine its correlation with the progression and prognosis of the tumor.
PATIENTS AND METHODS: A total of 144 paraffin-embedded specimens with advanced colon cancer were assessed for CXCR5 and CXCL13 by immunohistochemistry. Patients’ long-term survival was also monitored. There were significant differences in lymph node metastasis (p = 0.0066), neural invasion (p = 0.0061) and neural invasion (p = 0.0001) between high and low expression of CXCR5.
RESULTS: There were significant differences in distant metastasis (p = 0.0261), TNM stage (p = 0.0409), differentiation (p < 0.0001) and neural invasion of the CXCL13. Both CXCR5 and CXCL13 was associated with poor correlation with the overall survival (OS) and relapse-free survival (RFS).
CONCLUSIONS: Our data suggest that the CXCR5 and CXCL13 may play a crucial role in the development, metastasis and relapse of advanced colon cancer. They can be used as prognostic markers of colon cancer in clinical practice.
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To cite this article
X.-W. Qi, S.-H. Xia, Y. Yin, L.-F. Jin, Y. Pu, D. Hua, H.-R. Wu
Expression features of CXCR5 and its ligand, CXCL13 associated with poor prognosis of advanced colorectal cancer
Eur Rev Med Pharmacol Sci
Year: 2014
Vol. 18 - N. 13
Pages: 1916-1924