The correlation between MR diffusion-weighted imaging and pathological grades on glioma

S.-d. Chen, P.-f. Hou, L. Lou, X. Jin, T.-h. Wang, J.-l. Xu

Department of Neurosurgery, Zhejiang Provincial People’s Hospital, Hangzhou, Zhejiang, China. shuda_chen@263.net

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• Oncology

OBJECTIVE: This work intends to quantitatively analyze on pathological grade of glioma using Magnetic Resonance (MR) diffusion weighted imaging (DWI) and exploring the relativity of pathological grade and Apparent Diffusion Coefficient (ADC) value of MR diffusion weighted imaging.

PATIENTS AND METHODS: 40 patients with glioma accepted the MR diffusion weighted imaging to measure the ADC value of tumor with 3.0T MR machine before the surgery. Tumor samples were sent for pathologic diagnosis and tumor cell density measurement after the operation. The acquired data were analyzed statistically.

RESULTS: The ADC values of low-grade (WHO I-II) glioma were higher than that of high-grade (WHO III-IV), but the cell density of low-grade glioma was apparently lower than that of high-grade glioma. The ADC values and density of tumor cells were negatively correlated with WHO malignant grades, while the density of cells of glioma was positively correlated with WHO malignant grades.

CONCLUSIONS: MR diffusion weighted imaging is an objective and effective examination method.

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