Are insulin resistance and serum resistin levels increased in women with idiopathic hirsutism?

M. Erkan, M. Albayrak, A. Karatas, F. Keskin, Y. Aydin, H.Y. Ak, M. Erkan, I. Biyik

Department of Obstetrics and Gynecology, Duzce University School of Medicine, Duzce, Turkey. akaratas1973@hotmail.com

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• Endocrinology

OBJECTIVE: To investigate the insulin resistance and serum resistin levels in women with idiopathic hirsutism compared to controls and women with polycystic ovary syndrome (PCOS).

PATIENTS AND METHODS: Three groups of women including 23 women with idiopathic hirsutism, 28 women with PCOS and 28 non-hirsute women serving as controls were included into the study. The Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), serum fasting insulin and resistin levels were compared between the groups.

RESULTS: There were no statistically significant differences regarding the age, BMI and waist circumferences between the groups. Mean and median fasting blood glucose, fasting insulin, HOMA-IR, serum resistin levels were statistically similar between the groups (p = 0.966, p = 0.378, p = 0.409 and p = 0.784, respectively). There were no correlations between the resistin, HOMA-IR, fasting insulin levels and BMI in any of the three groups.

CONCLUSIONS: Insulin resistance and serum resistin levels do not appear to be increased in women with idiopathic hirsutism compared to controls at similar BMI’s and waist circumferences.

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