Evaluation of preoperative and postoperative S-100B levels in children with chronic adenotonsillar hypertrophy: preliminary results

F. Bozkus, S. Sarıkaya, O. Kocaturk, M. Calik, M. Abuhandan, A. Altintas, B. Koca, O.K. Guler, N. Aksoy, T. Ulas

Department of Otolaryngology Head and Neck Surgery, Harran University, Faculty of Medicine, Sanliurfa, Turkey. drferhat65@hotmail.com

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• Otorhinolaryngology

OBJECTIVES: Upper air obstruction leads hypoxia, it is also known that S-100B levels increase by glial activations indicate cerebral hypoxic injury. This study aimed to evaluate the preoperative and postoperative S-100B levels in children with chronic adenotonsillar hypertrophy.

PATIENTS AND METHODS: The study comprised 40 patients with indications for tonsillectomy and/or adenoidectomy following a diagnosis of chronic adenotonsillar hypertrophy and 40 age-gender matched control patients. Blood samples were taken from the patients preoperatively and at four weeks postoperatively. Preoperative and postoperative serum S-100B levels were analyzed.

RESULTS: The serum S-100B levels in the preoperative period were found to be significantly higher compared to those of the control group (p < 0.05). The S-100B levels were significantly decreased in the postoperative period (p < 0.05).

CONCLUSIONS: The development of chronic adenotonsillar hypertrophy would play a role in increased S-100B levels. This indicates that neuronal damage would exists in patients with chronic adenotonsillar hypertrophy.

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