Spontaneous regression of low-grade cervical intraepithelial lesions is positively improved by topical bovine colostrum preparations (GINEDIE®). A multicentre, observational, italian pilot study

C. Stefani, C.A. Liverani, V. Bianco, C. Penna, T. Guarnieri, C. Comparetto, E. Monti, I. Valente, A.L. Pieralli, C. Fiaschi, M. Origoni

Department of Obstetrics and Gynecology, Vita Salute San Raffaele University School of Medicine, Milan, Italy. massimo.origoni@hsr.it

 

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• Gynecology

OBJECTIVES: Human papillomavirus (HPV) is the causal agent of cervical cancer. The great majority of abnormal Pap test results – almost 90% – is referrable to either atypical squamous intraepithelial lesion or CIN1. For these lesions, worldwide agreement exists concerning the high rate – ranging from 40% to 70% – of spontaneous regression over a period of 1-5 years. Host’s immune response is a key point influencing the natural history of these conditions. Bovine colostrum is a natural agent positively promoting several immune activities against bacterial and viral agents. The aim of this report was to evaluate the potential positive effect of bovine colostrum-containing vaginal tablets administered to CIN1 diagnosed patients in a prospective trial in regards to spontaneous regression rate.

PATIENTS AND METHODS: A series of 256 consecutive patients with histologically proven CIN1 recruited in a multicentre, observational, Italian study. Patients have been enrolled in a 24-weeks protocol of treatment and re-tested at the end of the study. Rates of regression have been recorded.

RESULTS: Overall regression rate to a negative histology at the end of the 6 month follow up was 75.5%.

CONCLUSIONS: Regression to normal histology was observed in a very high rate of cases in a very short period compared to the natural history of these lesions. CIN1 patients could benefit from bovine colostrum topical administration in terms of significantly shortening the regression time.

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