Transcriptome network analysis reveals potential candidate genes for ankylosing spondylitis

Z.-Q. Zhu, J.-S. Tang, X.-J. Cao

Department of Orthopaedics, the First Affiliated Hospital of Nanjing Medical University, Nanjing, JiangSu Province, China. xiaojiancao@gmail.com

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• Rheumatology

OBJECTIVES: Ankylosing spondylitis (AS) is a chronic, inflammatory arthritis and autoimmune disease.

BACKGROUND: The main symptom of AS is inflammatory spinal pain; with time, some patients develop ankylosis and spinal immobility.

We aim to find cure available for ankylosing spondylitis.

MATERIALS AND METHODS: We used the GSE11886 series to identify potential genes that related to AS to construct a regulation network.

RESULTS: In the network, some of TFs and target genes have been proved related with AS in previous study, such as NFKB1, STAT1, STAT4, TNFSF10, IL2RA, and IL2RB. We also found some new TFs (Franscription Factors) and target genes response to AS, such as BXDC5, and EGFR. Further analysis indicated some significant pathways are associated with AS, including antigen processing and presentation and cytokine-cytokine receptor interaction, etc.; although not significant, there was evident that they play an important role in AS progression, such as apoptosis and systemic lupus erythematosus.

CONCLUSIONS: Therefore, it is demonstrated that transcriptome network analysis is useful in identification of the candidate genes in AS.

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