Effect of omega-3 fatty acids on cardiovascular risk factors in patients with type 2 diabetes mellitus and hypertriglyceridemia: an open study

D.A. de Luis, R. Conde, R. Aller, O. Izaola, M. González Sagrado, J.L. Perez Castrillón, A. Dueñas, E. Romero

Institute of Endocrinology and Nutrition, Medicine School and Hospital Rio Hortega, University of Valladolid, Valladolid (Spain) RETICEF RD056/0013

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• Internal Medicine

BACKGROUND AND OBJECTIVES:  Epidemiological and interventional studies suggest that a high dietary intake of n-3 polyunsaturated fatty acids may confer a protective effect against atherosclerotic disease and reduce serum triglycerides levels. The aim of our study was to investigate the effectivity on triglyceride levels and inflammatory markers of a concentrated of n-3 fatty acids in patients with type 2 diabetes mellitus and hypertriglyceridaemia.

SUBJECTS: A total of 30 patients (16 males and 14 females) with diabetes mellitus type 2 and hypertriglyceridemia (>200 mg/dl) were included in the study. Patients received two capsules of eicosapentaenoic 465 mg and docosahexanoic 375 mg daily for 12 weeks.

RESULTS: Triglycerides levels and non HDL-cholesterol decreased (326±113.5 vs. 216.4±57 mg/dl; p In conclusion, an n-3 polyunsaturated intervention improved lipid profile and inflammatory markers in patients with diabetes mellitus type 2 and hypertriglyceridaemia.

Corresponding Author: Daniel A. de Luis, MD; e-mail: dadluis@yahoo.es

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