Neutrophil lymphocyte ratios in stroke subtypes and transient ischemic attack

S. Gökhan, A. Özhasenekler, H. Mansur Durgun, E. Akil, M. Üstündag, M. Orak

Emergency Service, Diyarbakir Training and Research Hospital, Diyarbakir, Turkey. servan.gokhan@yahoo.com

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• Neurology

OBJECTIVES: This investigation was conducted to test the value of Neutrophil Lymphocyte Ratio (NLR), which has been shown in some recent studies to be a prognostically important and an easy-to-measure inflammatory marker, in patients presenting to Emergency Service with stroke (ischemic and hemorrhagic) and transient ischemic attack.

MATERIALS AND METHODS: A total of 868 patients were enrolled, who presented to our Emergency Service with cerebrovascular accident (stroke and transient ischemic attack) and admitted to Neurology Clinic. Demographic characteristics and comorbidities of patients were recorded. The patients were divided into 3 groups as acute ischemic stroke (AIS), acute hemorrhagic stroke (AHS) and transient ischemic attack (TIA). Patients with AIS were classified into subgroups in terms of TOAST (trial of 10172 stroke treatment) criteria. Admission NLR levels were compared across all groups.

RESULTS: A total of 868 patients were enrolled, 51.6% of which were male and 48.4% were female. AIS rate was 75.3%, AHS rate was 14.3% and TIA rate was 10.7%. In all of patients, mortality rate was 10.7%. NLR was significantly higher in patients who died (p < 0.001). NLR level in patients with TIA was significantly lower than those of AIS and AHS groups (p < 0.001). Among AIS subgroups, NLR level was significantly higher in group with great artery atherosclerosis or atherothrombosis compared to other groups (p < 0.001).

CONCLUSIONS: NLR may be used as a simple and easy-to-measure marker for prediction of short-term prognosis and in-hospital mortality in both ischemic and hemorrhagic stroke patients.

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