New biograft solution, growth factors and bone regenerative approaches in neurosurgery, dentistry, and orthopedics: a review

N. Montemurro, E. Pierozzi, A.M. Inchingolo, B. Pahwa, A. De Carlo, A. Palermo, R. Scarola, G. Dipalma, M. Corsalini, A.D. Inchingolo, F. Inchingolo, B. Rapone

Department of Neurosurgery, Azienda Ospedaliero Universitaria Pisana (AOUP), University of Pisa, Pisa, Italy. francesco.inchingolo@uniba.it

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• Dentistry
• Orthopedics

Bone regeneration following surgery, trauma, or any other condition is an autologous process that can fail, necessitating the requirement of novel procedures and materials. Recently, significant progress has been made in the research related to regenerative medicine. At the same time, biomedical implants in spine surgery, orthopedics, and dentistry are facing many challenges and posing clinical concerns.

A PubMed, MEDLINE, and Scopus review was carried out to identify all studies dealing with bone regenerative approaches in dentistry, orthopedics, and neurosurgery from database inception to December 2022.

There has been an upsurge in the implication of a multitude of materials in the enhancement of bone regeneration and/or neo-bone formation, including blood-derived growth factors, new biografts, biosynthetic polymers, inorganic compounds, and sea corals, in the very recent years. Stem cells (SCs) have been found to be efficacious and safe modalities in osteogenesis. Furthermore, bone regeneration/formation depends on the host’s immune system and metabolic condition. Epidermal growth factors (EGFs) and their receptors (EGFRs) are important in the mechanism of wound repairing and healing through the recruitment of stromal stem cells for epidermal and dermal regeneration. Similarly, biocomposite developed from Silica assembled with calcium and phosphorous has been utilized in the treatment of broken bones.

In this review, we summarized the clinical and laboratory evidence of bone regenerative approaches in the field of spine surgery, orthopedics, and dentistry. An accurate pre-operative screening is the key to managing and carefully planning all surgical steps and achieving the final success.

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