Evaluation of neutrophil-lymphocyte ratio, lymphocyte-monocyte, and monocyte-high density lipoprotein ratios in patients with fibromyalgia and determination of their relationship with disease activity, pain, and depression levels

A.G. Doğan

Physical Medicine and Rehabilitation Department, Hitit University Erol Olcok Training and Research Hospital, Corum, Turkey. drmdagu@gmail.com

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• Rheumatology

OBJECTIVE: This study aimed to evaluate neutrophil-lymphocyte ratio, lymphocyte-monocyte, and monocyte high-density lipoprotein ratios in patients with fibromyalgia and determine their relationship with disease activity, pain, and depression levels.

PATIENTS AND METHODS: This study was conducted with 40 healthy controls and 87 newly fibromyalgia (FM) diagnosed patients. Demographic characteristics, duration of pain, body mass index (BMI), and laboratory test results were recorded. The hematological indices and ratios were determined with a hemogram test. Disease activity was evaluated with a fibromyalgia impact questionnaire (FIQ). Depression status was evaluated with the beck depression inventory (BDI).

RESULTS: A total of 127 participants, 40 in the control group and 87 in the patient group, were included in the study. BMI values of the patient group were statistically higher than the control group (p=0.025). The white blood cell count of the patient group was statistically higher than the control group (p=0.007). Monocyte values were statistically higher in the patient group (p<0.001). Monocyte to high-density lipoprotein-cholesterol ratio (MHR) values in the patient group were statistically higher than the control group (p<0.001). Lymphocyte-monocyte-ratio (LMR) values of the control group were statistically higher than the patient group (p<0.001).

CONCLUSIONS: This study shows that in fibromyalgia patients, monocyte level and MHR were higher than in healthy subjects. Also, high-density lipoprotein-cholesterol (HDL-C) level was found lower, and the total cholesterol level was found higher in patients with FM. Increased LMR and HDL-C values were found as responsible for decreasing the risk of developing FM and increased glucose and total cholesterol values were responsible for increasing the risk of FM developing.

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