The protective effects of hesperidin pretreatment on kidney and remote organs against renal ischemia-reperfusion injury

C. Karacaer, D.G. Erdogan, A. Tanyeli, H. Baylan, E. Eraslan, M.C. Guler, E. Polat, S. Comakli

Department of Internal Medicine, Sakarya University Training and Research Hospital, Sakarya, Turkey. karacaerc@yahoo.com

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• Internal Medicine

OBJECTIVE: As an antioxidant and anti-inflammatory agent, Hesperidin was investigated to prove whether it prevents damage to the kidney and lung tissues of rats undergoing renal ischemia-reperfusion injury.

MATERIALS AND METHODS: Four groups of rats were set, including eight subjects each as Group 1 (control), Group 2-RIR (renal ischemia reperfusion), Groups 3 and 4 as pretreatment groups (50 HES, 100 HES).

RESULTS: According to our results, Hesperidin pretreatment improved the biochemical and histopathological parameters in kidney and lung tissues of rats with ischemia-reperfusion injury. Besides, a 100 mg/kg dose of Hesperidin was found to be more beneficial to the rats than 50 mg/kg.

CONCLUSIONS: The study suggests that Hesperidin is protective against renal and lung tissues of rats that underwent ischemia-reperfusion injury.

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