Estrogens and euosteogenesis in men

D. Maugeri, P. Panebianco, P. Barbagallo, M. Malaguarnera, M.P. Curasi, M.S. Russo, A. Santangelo, S. Speciale, R.A. Scarpinato

Institute of Internal Medicine and Geriatrics, Catania University (Italy)

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• Endocrinology
• Internal Medicine

Abstract. – The bone mineral density (BMD) has been analyzed in 200 male patients divided in 4 groups of age as follows: (A) 40-49, (B) 50-59, (C) 60-69, and (D) 70 years and above. BMD was measured by using the DEXA technique both in the ultradistal and mediodistal region of radius of the non-dominant side. In addition, the serum levels of testosterone (Ts), dihydrotestosterone (DHT) and 17-beta estradiol (E-2) have also been measured. The data obtained have shown that bone mineral density values are decreasing also in the males with advancing age, and the positive correlation (p< 0.05) of BMD with the E-2 levels also tend to decrease. These results suggest the hypothesis that the true sexual hormones regulating the rhythm of osteogenesis may be the estrogens in the males too.

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