Effects of CAR structure and culture conditions on memory CAR-T cells

W.-C. Pei, J. Hu, J.-H. Song, W.-F. Wang, Y.-Y. He, W.-J. Pang, Y. Huang

Department of Gastroenterology, Civil Aviation Hospital of Shanghai, Shanghai, China. wencengpei@126.com

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• Pharmacology

Adoptive CAR T cell therapy (chimeric antigen receptor T-Cell) has received increasing attention in recent years; however, its efficacy is undesirable and differs from person to person. Understanding how to overcome this obstacle is important to improve therapy. Infusion of poorly differentiated CAR-CD62L+ T cells, such as T memory stem cell populations, leads to enhanced T cell implantation, expansion, and persistence, which ultimately leads to more stable tumour regression. Here, we reviewed emerging findings demonstrating that CAR structure and cell culture conditions can influence CAR T cell differentiation and antitumour efficacy.

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