Quinacrine as a potential treatment for COVID-19 virus infection
B. Pineda, V. Pérez de la Cruz, R. Hernández Pando, J. Sotelo Laboratorio de Neuroinmunología y Neurooncología, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México. benpio76@hotmail.com
A novel coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a current outbreak of infection termed Coronavirus Disease 2019 (COVID-19) by the World Health Organization (WHO). COVID-19 is currently a global pandemic that may cause close to half a billion deaths around the world. Until now, there is no effective treatment for COVID-19. Quinacrine (Qx) has been used since the 1930s as preventive antimalarial compound. It is a recognized small molecule inhibitor of RNA virus replication, with known anti-prion activity, and identified as a potent Ebola virus inhibitor both in vitro and in vivo. Recently, Qx has showed anti-SARS-CoV-2 activity. Herein, we review the potential mechanisms associated with quinacrine as an antiviral compound.
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To cite this article
B. Pineda, V. Pérez de la Cruz, R. Hernández Pando, J. Sotelo
Quinacrine as a potential treatment for COVID-19 virus infection
Eur Rev Med Pharmacol Sci
Year: 2021
Vol. 25 - N. 1
Pages: 556-566
DOI: 10.26355/eurrev_202101_24428