Eur Rev Med Pharmacol Sci 2020; 24 (23): 12324-12333
DOI: 10.26355/eurrev_202012_24025

LncRNA LncOGD-1006 alleviates OGD-induced ischemic brain injury regulating apoptosis through miR-184-5p/CAAP1 axis

J.-Y. Chen, H. Chen, T. Li, L. Yang, X.-M. Ye, W.-Y. Gao, S.-P. Zhang, L. Zong

Department of Neurology, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, China. iiorfguj@163.com

OBJECTIVE: This study aimed to explore the effect of long non-coding RNA (LncRNA) LncOGD-1006 to ischemic stroke and the possible mechanism.

MATERIALS AND METHODS: The primary brain microvascular endothelial cells (bEnd.3) of oxygen-glucose deprivation (OGD) was used as a mimic of ischemic stroke in vitro.

RESULTS: The results showed that LncOGD-1006 was upregulated in bEnd.3 after OGD-induced.

CONCLUSIONS: LncOGD-1006 might act as a ceRNA to inhibit apoptosis in bEnd.3 cells by targeting miR-184-5p/CAAP1 pathway.

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To cite this article

J.-Y. Chen, H. Chen, T. Li, L. Yang, X.-M. Ye, W.-Y. Gao, S.-P. Zhang, L. Zong
LncRNA LncOGD-1006 alleviates OGD-induced ischemic brain injury regulating apoptosis through miR-184-5p/CAAP1 axis

Eur Rev Med Pharmacol Sci
Year: 2020
Vol. 24 - N. 23
Pages: 12324-12333
DOI: 10.26355/eurrev_202012_24025

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