Diagnostic value of miRNA-122 in Kawasaki disease

H.-F. Lv, X.-Q. Sun, H.-X. Zhou, Z. Qin, Y.-Y. Shi, Q. Wang, F. Li

Department of Pediatrics, Taizhou Jiangyan Hospital of Traditional Chinese Medicine, Taizhou, China. mlfsfm2@163.com

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• Cardiology

OBJECTIVE: To explore the expression pattern and diagnostic value of microRNA-122 (miRNA-122) in childhood Kawasaki disease (KD).

PATIENTS AND METHODS: A total of 150 children with KD were included in the KD group. During the same period, 150 children with respiratory infection complicated with fever and without myocardial involvement were included in the control group.  Serum level of miRNA-122 in children with acute phase of KD and those in the control group was detected. The relationship between serum level of miRNA-122 and clinical features of KD was analyzed by Pearson correlation test. ROC curves were depicted to assess the diagnostic value of miRNA-122 in KD.

RESULTS: Serum level of miRNA-122 was higher in the KD group than controls. In the acute phase of KD, the serum level of miRNA-122 was positively correlated to CRP and NT-proBNP, while negatively correlated to the sodium level. The specificity and sensitivity of miRNA-122 in diagnosing KD was 78.67% and 84.67%, respectively (AUC=0.8861, cut-off value=2.905).

CONCLUSIONS: Serum level of miRNA-122 is significantly enhanced in the acute phase of KD, and highly expressed miRNA-122 is related to systematic inflammation. MiRNA-122 may be used as a diagnostic hallmark of KD.

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