LncRNA HMGA1P4 promotes cisplatin-resistance in gastric cancer

X.-L. Qiao, Z.-L. Zhong, Y. Dong, F. Gao

Department of Gastroenterology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China. gaofei_19790813@163.com

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• Oncology

OBJECTIVE: Long non-coding RNA (lncRNA) HMGA1P4 has been previously reported to be upregulated in gastric cancer (GC). This study aims to investigate the role of HMGA1P4 in cisplatin (DDP)-resistant GC.

PATIENTS AND METHODS: HMGA1P4 levels in DDP-resistant GC tissues and cells were determined. Regulatory effects of HMGA1P4 on proliferative and apoptotic abilities in DDP-resistant GC cells and their parental cells were assessed. At last, expression levels of genes associated with multidrug-resistance (MDR) (MDR1, MRP1, mTOR and HIF-1α) and apoptosis (Bax, Bcl-2 and Caspase3) were determined in DDP-resistant GC cells.

RESULTS: Results revealed that HMGA1P4 was upregulated in DDP-resistant GC tissues and cells. Overexpression of HMGA1P4 stimulated proliferative rate and suppressed apoptosis in both DDP-resistant GC cells and their parental cells. Moreover, in DDP-resistant GC cells, overexpression of HMGA1P4 upregulated MDR-related genes and downregulated apoptosis-related genes.

CONCLUSIONS: HMGA1P4 is upregulated in DDP-resistant GC tissues and cells, and triggers the progression of DDP-resistance in GC.

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