Functional characterization of the long noncoding RNA MIR22HG as a tumour suppressor in cervical cancer by targeting IGF2BP2

J. Shu, D. Wang

Key Laboratory for Biorheological Science and Technology of Ministry of Education (Chongqing University), Chongqing University Cancer Hospital, Chongqing, China. wangdong19691220@cqu.edu.cn

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• Oncology

OBJECTIVE: Cervical cancer is the most common malignant tumour in the female reproductive tract, ranking second in the global cause of female cancer and seriously endangering women’s health. However, the underlying mechanisms leading to cervical cancer are unclear. Previous studies have reported the roles and general underlying mechanisms of the long noncoding RNA MIR22HG (MIR22HG) in multiple types of tumours.
PATIENTS AND METHODS: In this study, we describe the functional role of MIR22HG as a tumour suppressor lincRNA by regulating metastasis, growth and invasion by performing a series of in vivo and in vitro experiments.
RESULTS: Our data suggested that MIR22HG dramatically promoted cervical cancer apoptosis and inhibited invasion by targeting IGF2BP2.
CONCLUSIONS: The long noncoding RNA MIR22HG targets IGF2BP2 as a tumour suppressor in cervical cancer. Our findings will be helpful for developing potential therapeutics for cervical cancer.

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