Clinical efficacy and prognosis of aspirin combined with clopidogrel in patients with cerebral hemorrhage after operation

X.-J. Guo, W.-L. Ding, H.-H. Zhu

Department of Emergency, Affiliated Hospital of Jining Medical University, Jining, P.R. China. bh7u52@163.com

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• Pharmacology

OBJECTIVE: The aim of this study was to investigate clinical effect, the quality of life, and prognosis of patients with hypertensive cerebral hemorrhage treated with aspirin combined with clopidogrel after decompressive craniectomy and removal of intracranial hematoma.

PATIENTS AND METHODS: The individual patient data of 120 patients with hypertensive cerebral hemorrhage admitted to Affiliated Hospital of Jining Medical University from January 2015 to July 2016 were retrospectively analyzed. The patients were divided into a research group (62 cases) and a control group (58 cases). The control group was treated with aspirin, while the research group was treated with aspirin combined with clopidogrel. The prevalence of adverse reactions was compared between the two groups. Activity of daily living (ADL) was used to evaluate the quality of life. The amount of hematoma before and after operation was compared between the two groups. The prognosis of the two groups and the risk factors of postoperative rebleeding in patients with cerebral hemorrhage were analyzed.

RESULTS: The prevalence of adverse reactions in the research group was significantly higher than that in the control group (p<0.05). The ADL scores of both groups 14 days after the operation were higher than those before the operation (p<0.05), and the ADL scores of the research group were significantly lower than those of the control group 14 d after the operation (p<0.05). The amount of hematoma in the two groups after surgery was lower than that before surgery (p<0.05), and the amount of hematoma in the research group was higher than that in the control group (p<0.05).

CONCLUSIONS: The combination of aspirin and clopidogrel will increase the prevalence of adverse reactions and reduce the quality of life of patients after decompressive craniectomy and removal of intracranial hematoma in patients with hypertensive intracerebral hemorrhage. Careful medication is required in clinic.

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