OBJECTIVE: The suppressors of cytokine signaling 3 (SOCS3) negatively regulates the JAK-STAT pathway. The bioinformatics analysis revealed a targeted binding site between miR-221 and the 3’-UTR of SOCS3 mRNA. This study investigated the role of miR-221 in the proliferation and apoptosis of gastric cancer cells. PATIENTS AND METHODS: The Dual-Luciferase reporter gene assay validated the … Continue reading MiR-221 affects proliferation and apoptosis of gastric cancer cells through targeting SOCS3