Circular RNA circ_0067934 functions as an oncogene in glioma by targeting CSF1

X.-L. Cui, X.-D. Wang, S.-K. Lin, C.-M. Miao, M. Wu, J.-G. Wei

Department of Neurosurgery, Jilin Beihua University Affiliated Hospital, Jilin, China. 2645298806@qq.com

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• Oncology

OBJECTIVE: The importance of circular RNAs in malignant tumors increases the attention of researchers. The role of circ_0067934 in glioma remains unclear. Our study aims to uncover how circ_0067934 functions in glioma development.

PATIENTS AND METHODS: Real Time-quantitative Polymerase Chain Reaction (RT-qPCR) was utilized to determine the level of circ_0067934 in glioma tissues. Circ_0067934 was knocked down in glioma cells. Cell migrated and invaded ability was detected through functional assay in vitro and in vivo. Further mechanism assays were performed to explore the potential targets of circ_0067934.

RESULTS: The circ_0067934 was highly expressed in glioma tissues compared with adjacent samples. The expression of circ_0067934 was upregulated in glioma cell lines. The cell migrated and invaded ability of glioma cells was inhibited after circ_0067934 was knocked down. Besides, CSF1 expression was decreased via knockdown of circ_0067934. Furthermore, tumor metastasis was inhibited after circ_0067934 was knocked down in nude mice.

CONCLUSIONS: The circ_0067934 could suppress cell migration and invasion of glioma by upregulating CSF1.

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