Analysis on the correlations of ENOS and ET-2 gene polymorphisms with eclampsia

N. Yu, L. Fan, J.-L. Wu, S.-H. Chen, W. Li

Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. topliwei@163.com

---

• Obstetrics

OBJECTIVE: To explore the correlations of endothelial nitric oxide synthase (eNOS) G894T and endothelin-2 (ET-2) A985G gene polymorphisms with eclampsia.

PATIENTS AND METHODS: A total of 110 eclampsia patients in our hospital from July 2014 to August 2017 were enrolled as the observation group and 100 healthy pregnant women in the same period as the control group. The polymorphisms of eNOS G894T and ET-2 A985G genes in the two groups were analyzed via polymerase chain reaction (PCR), and their correlations with eclampsia risk were investigated.

RESULTS: The distribution frequency of eNOS G894T genotype TT and GT and T allele, as well as the ET-2 A985G genotype GG and AG and G allele, were evidently higher in the observation group than in the control group (p<0.05). ENOS G894T genotype TT and ET-2 A985G genotype GG were significantly associated with the occurrence of eclampsia.

CONCLUSIONS: The polymorphisms of eNOS G894T and ET-2 A985G genes are correlated with the occurrence of eclampsia.

Free PDF Download