Correlations of TIMP2 and TIMP3 gene polymorphisms with primary open-angle glaucoma

M.-L. Ji, J. Jia

Department of Ophthalmology, The Second Affiliated Hospital of Xi’an Medical University, Xi’an, China. gqzd69@163.com

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• Ophthalmology

OBJECTIVE: To explore the correlations of the tissue inhibitor of metalloproteinase-2 (TIMP2) and TIMP3 gene polymorphisms with primary open-angle glaucoma (POAG).
PATIENTS AND METHODS: 295 POAG patients were recruited as the observation group and 200 healthy people as the control group. The general clinical information, medical history (hypertension, diabetes and hyperlipemia) and family history were collected. The vascular endothelium and hemorheology indexes in each group were detected. Moreover, the polymorphisms of TIMP2 rs796391657 and TIMP3 rs8136803 were detected via TaqMan-MGB probe assay.
RESULTS: The observation group exhibited higher prevalence rates of diabetes, hyperlipemia and family history than those of the control group (p<0.05), and there were no differences in age, sex and hypertension prevalence rate between the two groups (p>0.05). The observation group had a lower nitric oxide (NO) level, but higher levels of endothelin-1 (ET-1), plasma viscosity (PV), hematocrit (HCT) and fibrinogen (FIB) than those of the control group (p<0.05). The distribution of the three genotypes and alleles of TIMP2 rs796391657 varied a lot between the two groups (p<0.05). The frequency of genotype CC was markedly higher than that of genotype TT; however, C allele had a higher frequency than T allele. Similarly, the three genotypes and alleles of TIMP3 rs8136803 were differentially distributed in the two groups (p<0.05). The frequency of genotype GG was higher than that of genotype TT, while the frequency of G allele was higher than that of T allele.
CONCLUSIONS: The TIMP2 and TIMP3 gene polymorphisms are correlated with POAG.

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