OBJECTIVE: Myocardial fibrosis seriously affects normal heart function. This study focused on the role of microRNA-199a in regulating rat myocardial fibrosis by targeting secreted frizzled-related protein 5 (SFRP5). MATERIALS AND METHODS: The in vitro myocardial fibrosis model was established by 10 μM isoproterenol (ISO) induction in cardiac fibroblasts (CFs) for 24 h. Expression levels of … Continue reading MicroRNA-199a regulates myocardial fibrosis in rats by targeting SFRP5