Clinicopathological and prognostic significance of miR-4317 expression in gastric cancer patients

J. Zhang, Z.-L. Tian, W.-T. Zhang, L.-M. Cheng, J. Liu, Y.-X. Cao, Z.-R. Zhang

Department of Gastroenterology, Jining No. 1 People’s Hospital Affiliated to Jining Medical University, Jining, Shandong, China. zran54712@sina.com

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• Oncology

OBJECTIVE: Previous studies have revealed that miR-4317 was abnormally expressed and functioned as a tumor suppressor in several tumors, including gastric cancer (GC). However, the clinical significance of miR-4317 in GC remains largely unclear. Our present study aimed at investigating the possibility of miR-4317 as a novel prognostic biomarker for GC patients.
PATIENTS AND METHODS: RT-PCR was performed to determine the levels of miR-4317 in GC tissues and matched normal gastric tissues. Association between miR-4317 levels and clinicopathological factors was also analyzed using Chi-square test. Kaplan-Meier survival analysis and univariate and multivariate assays were further conducted to investigate the correlation between miR-4317 expression and GC patients prognosis.
RESULTS: We showed that miR-4317 expression levels were significantly lower in GC cell lines compared to matched normal tissues (p< 0.01). Down-regulation of miR-4317 was observed to be associated with lymph node metastasis (p = 0.019), distant metastasis (p = 0.011) and TNM stage (p = 0.007). In addition, Kaplan-Meier analysis showed that patients with low miR-4317 expression had a shorter overall survival compared with the high miR-4317 expression group (p = 0.0009). Furthermore, multivariate analysis revealed that miR-4317 expression was an independent prognostic marker of overall survival of GC patients.
CONCLUSIONS: miR-4317 expression may be a novel and valuable prognostic factor in GC.

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