The correlation between AGT gene polymorphism and neonatal hypoxic-ischemic encephalopathy (HIE)

H.-M. Chen, L.-X. Gao, J.-J. Wang, C. Gao

Department of Disease Control, Zhengzhou University Affiliated Children’s Hospital, Henan Children’s Hospital Hospital, Zhengzhou Children’s Hospital, Zhengzhou, China. Gaochao996@sina.com

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• Neurology

OBJECTIVE: To explore the correlation between the rs2067853 polymorphism in angiotensinogen (AGT) gene and neonatal hypoxic-ischemic encephalopathy (HIE).

PATIENTS AND METHODS: A total of 96 neonatal patients with HIE and 123 healthy neonates were selected. General clinical data were collected and TaqMan-MGB probe method was adopted to detect the rs2067853 polymorphism in angiotensinogen (AGT) gene.

RESULTS: The frequency of advanced maternal age, low maternal age, maternal renal insufficiency, abnormal labor, amniotic fluid contamination and umbilical cord abnormality in the observation group was higher than that in the control group (p<0.05), and there was no significant difference between the two groups in the frequency of pregnancy-induced hypertension or eclampsia, maternal anemia, routine prenatal examination, natural childbirth, placental abnormality and abnormal birth weight (p>0.05). There was a difference in genotype distribution frequency between the two groups (p<0.05), while there was no difference in the allele distribution frequency between the two groups (p>0.05). The recessive model had differences between the two groups (p<0.05), while the dominant and additive model had no differences between the two groups (p>0.05).

CONCLUSIONS: HIE is correlated with maternal factors, fetal growth, uterine environment and labor process, and the rs2067853 polymorphism in AGT gene is associated with HIE.

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