Elevated long non-coding RNA LINC00958 was associated with metastasis and unfavorable prognosis in gastric cancer

W. Wang, Z.-J. Song, Y. Wang, W.-F. Zhong, P. Kang, Y. Yang

Department of Surgery, Zhangqiu District Maternal and Child Health Care Hospital, Jinan, Shandong, China. dryangyang88@foxmail.com

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• Oncology

OBJECTIVE: To investigate the clinicopathological significance of long non-coding LINC00958 and its expression in gastric cancer (GC).

PATIENTS AND METHODS: A total of 200 patients with GC whose sample tissues were enrolled. Total RNA was isolated using the TRIzol method followed by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) detection of LINC00958 on mRNA level. The correlation was analyzed using Chi-square test, between the LINC00958 expression versus clinicopathological variables, including age, gender, clinical stage, tumor size, TNM classification and overall prognosis. The Kaplan-Meier survival curve was used to assess the prognostic value of LINC00958 expression, after which univariate and multivariate analysis was carried out with the COX proportional hazard analysis.

RESULTS: LINC00958 was shown to be dramatically elevated in GC relative to normal controls. Elevated LINC00958 significantly correlated with lymph nodes metastases, distance metastasis, peritoneal dissemination, and peritumoral tissues infiltration (p<0.05). The Kaplan-Meier survival analysis showed that up-regulated LINC00958 was markedly associated with inferior overall survival (p<0.001). In addition, multivariate analysis highlighted that LINC00958 expression was an independent prognostic factor in GC.

CONCLUSIONS: Our observation revealed that elevated LINC00958 was significantly associated with metastasis and was an independent prognostic factor in GC, indicating that LINC00958 can serve as a novel prognostic predictor in GC.

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