Endocan: a biomarker predicting successful reperfusion after coronary artery by-pass surgery of acute coronary syndrome patients

A.O. Cimen, S. Emet, A. Elitok

Department of Cardiology, Istanbul Bahcesehir University Medical Faculty, Istanbul, Turkey. samim.emet@istanbul.edu.tr

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• Pharmacology

OBJECTIVE: Endothelial specific molecule 1 (Endocan) is a biomarker of the inflammatory process occurring in endothelial cells. It was shown that endocan was increased in acute coronary syndromes. We aimed at investigating the endocan levels in acute coronary syndrome patients after coronary bypass surgery.

PATIENTS AND METHODS: The study included 35 patients who presented with acute coronary syndrome to the Emergency Department. Serum endocan levels and other inflammatory markers were evaluated before and after coronary artery by-pass surgery. The correlation coefficients and their significance were calculated by Pearson’s test and the difference in mean values before and after bypass surgery was calculated by paired sample t-test. Statistical analyses were performed using SPSS version 20.0 (SPSS Inc., Chicago, IL, USA). Statistical significance was taken as p<0.05.

RESULTS: There was a significant change in serum hs-CRP and endocan levels and also LVEF before and after CABG operation (p<0.05).

CONCLUSIONS: Serum endocan level was significantly decreased after successful reperfusion in our study. Thus, it may be an important biomarker in terms of clinical use as an indicator of successful reperfusion.

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