The role of FH detection combined with HPV screening on the diagnostic significance of cervical cancer and precancerous lesions

Y.-J. Hu, H.-P. Zhang, B. Zhu, H.-Y. Chen, L.-H. Ma, Y. Wang

Department of Obstetrics and Gynecology, The Wenzhou People’s Hospital, Wenzhou, Zhejiang, China. xin72628088@163.com

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• Oncology

OBJECTIVE: Cervical cancer is a common type in gynecologic malignant tumor that accounts for the leading morbidity only after breast cancer in female. This study aims to determine the diagnostic significance of uterine epithelial cells stability free body of iron protoporphyrin reduced state (FH) detection combined human papillomavirus (HPV) screening for cervical cancer.

PATIENTS AND METHODS: A total of 800 patients were enrolled. FH test and HPV genotyping detection were performed. The cases with abnormal results were treated by colposcopy. Pathological detection was treated as the golden standard. Coincidence rate, sensitivity, and specificity were calculated.

RESULTS: The positive rate of FH and high-risk HPV rate were 11.5% and 16.5%, respectively. The coincidence rate of single FH detection positive and negative was 76.08% and 85.71%, respectively. FH detection exhibited sensitivity of 74.26% and specificity of 61.22%. The coincidence rate of single positive and negative HPV test was 53.03% and 88.58%, respectively. HPV screening presented sensitivity of 77.25% and specificity of 65.37%. The coincidence rate of positive and negative combined detection was 92.11% and 100%, respectively. The sensitivity and specificity of combined detection was 96.32% and 81.22%, respectively, which was significantly higher than that of single detection group (p < 0.05).

CONCLUSIONS: FH detection combined with HPV screening is efficient in the diagnosis of cervical cancer and precancerous lesion, which is better than single use of FH detection. Our data highlight the importance of FH with HPV screening for the clinical application.

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