Correlations between the expression of C-erB-2, CD34 and ER in breast cancer patients and the signs of conventional ultrasonography and ultrasound elastography

Y. Liu, W. Xiong, J.-M. Xu, Y.-X. Liu, J. Zhang

Department of Ultrasound Diagnosis, China Meitan General Hospital, Chaoyang District, Beijing, P.R. China. jzhang76@sina.com

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• Oncology

OBJECTIVE: This study aims to investigate the correlations between the expression of human epidermal growth factor receptor 2 (C-erB-2), CD34, and estrogen receptor (ER) in breast cancer (BC) patients, and the signs of conventional ultrasonography and ultrasound elastography.

PATIENTS AND METHODS: Clinical data of 88 patients who were pathologically diagnosed as breast cancer were retrospectively analyzed. HI VISION Avius color ultrasound device was used to perform ultrasound and related ultrasound parameters were analyzed. Expressions of C-erB-2, CD34, and ER were detected by immunohistochemistry.

RESULTS: There was a correlation between positive expression of C-erB-2 and the blood supply, lymph node metastasis and microcalcification in patients (p < 0.05). Patients were divided into high expression group and low expression group according to the median expression level of CD34. Expression of CD34 was correlated with the ultrasound sign of lymph node metastasis (p < 0.05). Positive expression of ER was correlated with the morphology, margin, and perimeter of the tumor (p < 0.05). Expression levels of C-erB-2, CD34, and ER were found to be increased in BC patients.

CONCLUSIONS: Combination of upregulated expression of C-erB-2, CD34, and ER and signs of ultrasound can improve the diagnosis of BC.

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