The clinical effects of gonadotropin-releasing hormone agonists for the treatment of children patients with central precocious puberty

Y. Xue, P. Wang, S.-Q. Wang, Y.-Q. Gao

Department of Endocrinology, Xuzhou Children’s Hospital, Xuzhou, Jiangsu, P.R. China. xueying96@yeah.net

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• Pharmacology

OBJECTIVE: We explored the clinical effect of gonadotropin-releasing hormone agonists for the treatment of children patients with central precocious puberty.

PATIENTS AND METHODS: From March 2012 to October 2015, 100 cases of children patients with central precocious puberty were enrolled in this study. Intramuscular injection of acetic acid triptorelin (50 to 100 pLg/kg) was made once every 4 weeks, and the treatment lasted for 4 months. Patients’ bone age/height differentials (DBA/DCA), bone age (BA), growth velocity (GV) and predicted adult height (PAH) were determined before and after treatment (after 6, 12, 24, 36 months). Differences before and after treatment were analyzed. DBA/DCA, BA and PAH values 6, 12, 24, 36 months after treatment were significantly different compared with those before treatment.

RESULTS: Sexual development symptoms in children patients were significantly improved 4 months after treatment (p<0.05). All patients completed the treatment, without any adverse drug reaction or severe complication. After one course of treatment (4 months), patients’ uterus and ovarian volumes shrank, FSH level peaked, and LH level was reduced, compared to those before treatment.

CONCLUSIONS: Acetate acid triptorelin is safe and reliable for treating central precocious puberty. We achieved the excellent clinical curative effect and were able to delay the growth rate in children patients. The predicted height and final height were improved.

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