Evaluation of the prognostic value of LMR, PLR, NLR, and dNLR in urothelial bladder cancer patients treated with radical cystectomy

P. Rajwa, M. Życzkowski, A. Paradysz, K. Bujak, P. Bryniarski

Department of Urology, School of Medicine with the Division of Dentistry in Zabrze, Medical University  of Silesia in Katowice, Zabrze, Poland. pawelgrajwa@gmail.com

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• Oncology

OBJECTIVE: Our aim was to evaluate the association between preoperative LMR, PLR, NLR, dNLR, and survival of urothelial bladder cancer (UBC) patients treated with radical cystectomy (RC). We also analyzed the relationship between preoperative blood-based inflammatory biomarkers’ levels and postoperative in-hospital complications.

PATIENTS AND METHODS: This retrospective study included 144 UBC patients, who underwent RC between 2003 and 2015. The study endpoints were cancer-specific survival (CSS) and overall survival (OS).

RESULTS: Univariable analysis revealed that continuous LMR, PLR, NLR and dNLR were significantly associated with CSS and OS. On multivariable regression model analysis, continuous LMR, NLR, and dNLR independently predicted both endpoints. Furthermore, the group of patients with lower LMR values had a greater chance of developing postoperative in-hospital complications.

CONCLUSIONS: Our findings indicate that the cheap and simple blood-based biomarkers may be valuable in identifying UBC patients treated with RC, who are at higher risk of all-cause and cancer-related mortality.

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