Low-expression of lncRNA FER1L4 might be a prognostic marker in osteosarcoma

Z.-X. Chen, C.-P. Chen, N. Zhang, T.-X. Wang

Department of Orthopedics, Yidu Central Hospital of Weifang, Qingzhou, China. yishengkeyan@163.com

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• Oncology

OBJECTIVE: To investigate the potential role of Long non-coding RNA (lncRNA) FER1L4 in the diagnosis and prognostic assessment of osteosarcoma.

PATIENTS AND METHODS: LncRNA FER1L4 expression in osteosarcoma samples was detected by real-time PCR. The Kaplan-Meier method was used to analyze the relationship between lncRNA FER1L4 expression and the survival time of patients.

RESULTS: LncRNA FER1L4 expression was decreased in osteosarcoma samples. LncRNA FER1L4 was not related to the gender and age of patients, but was significantly associated with disease stage, metastasis, and tumor differentiation.

CONCLUSIONS: Low-expression of lncRNA FER1L4 might be a prognostic marker in osteosarcoma.

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