The molecular mechanism of serum microRNA124b induced coronary heart disease by inducing myocardial cell senescence

M.-L. Guo, L.-L. Guo, Q.-J. Qin, Y.-Q. Weng, Y.-N. Wang, J. Yao, Y.-B. Wang, X.-Z. Zhang, Z.-M. Ge

Department of Cardiology, Qilu Hospital of Shandong University, Jinan, Shandong, China. zhiminggert@163.com

---

• Cardiology

OBJECTIVE: The incidence and mortality of coronary heart disease are rapidly increasing in recent years. Myocardial cell dysfunction and cell senescence may play a role in coronary heart disease. MicroRNA controls a variety of biological processes, but leaving its role in coronary heart disease has yet to be explored.

PATIENTS AND METHODS: Patients with coronary heart disease were regarded as subjects, and healthy volunteers as the control, on both of which microRNA124b level of serum was studied by Real-time PCR, and the heart function of patients was detected by using ultrasound. The relationship between serum microRNA124b level and cardiac function was analyzed along with the model of rat coronary artery disease; the level of aging proteins P21 and P53 in cardiac muscle cells was also tested.

RESULTS: MicroRNA124b in the serum of patients with coronary heart disease was increased, and the heart function of patients was decreased (p < 0.05). Serum level of microRNA124b in a rat model of coronary heart disease was increased, and the cardiac function was decreased (p < 0.05). When myocardial cell appeared ageing, the level of P21 and P53 was increased, and the level of microRNA124b was related with P53.

CONCLUSIONS: The level of microRNA124b in the serum of coronary heart disease patients and rat model may be related to the occurrence of coronary heart disease; microRNA124b may lead to the occurrence of coronary heart disease by causing cell senescence.

This article has been withdrawn. The Publisher apologizes for any inconvenience this may cause.

Free PDF Download