Reveals new lung adenocarcinoma cancer genes based on gene expression

Z.-F. Lin, X.-Y. Shen*, F.-Z. Lu*, Z. Ruan, H.-L. Huang, J. Zhen

Department of Thoracic Surgery, Shanghai First People’s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China. linzhifeng2611@163.com
* Department of Thoracic Surgery, The Huadong Hospital, Shanghai Fudan University, Shanghai, China

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• Oncology

BACKGROUND: Lung adenocarcinoma (LAC) is the most common type of lung cancer, accounting for 30-35% of all cases.

AIM: In this study we aim to predict potential genes and confirm pathways which are associated with LAC.

MATERIALS AND METHODS: By using the meta-analysis method, GSE10072 and GSE 2514 datasets were merged to find potential genes and pathways which are associated with LAC.

RESULTS: Our analysis indicated identified differentially expressed genes enriched in multicellular organismal metabolic process, gland development, and urogenital system development. Further, we predicted genes including EGF-like domain might be the potential target genes for further study, such as NGX6, MUC17, and Nel. In addition, a number of genes that associated with axon guidance, focal adhesion, and complement and coagulation cascades pathway might be also involved in LAC in a direct or indirectly manner.

CONCLUSIONS: Our analysis indicated identified differentially expressed genes enriched in multicellular organismal metabolic process, gland development, and urogenital system development We anticipate numerous advances in LAC research in the coming years based on our meta-analysis.

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