Clinical value of combined detection of serum APE1-Aabs and CEACAM-1 in the diagnosis of colorectal cancer

W. Huajun, F. Ying, Z. Hongxing, S. Weifeng, S. Pingyang, H. Mingde, L. Guoguang

Jiaxing First Hospital, Jiaxing, Zhejiang Province, China. 39882983@qq.com

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• Oncology

OBJECTIVE: To analyze the clinical value of combined detection of serum APE1-Aabs and CEACAM-1 in pathological diagnosis of colorectal cancer.

PATIENTS AND METHODS: From December 2014 to July 2016, 60 patients with colorectal cancer and 50 healthy subjects were enrolled in this study. The levels of APE1-AAbs, CEACAM-1 and CEA in the serum were measured, and the clinical value of each index in the diagnosis of colorectal cancer was analyzed.

RESULTS: The level of serum APE1-AAbs in colorectal cancer group was significantly higher than that in healthy control group (p < 0.05). The levels of serum CEACAM-1 and CEA in colorectal cancer patients were significantly higher than those in healthy control group (p < 0.05). The sensitivity and accuracy of APE1-AAbs and CEACAM-1 in the diagnosis of colorectal cancer were significantly higher than separate detection of APE1-AAbs, CEACAM-1 or CEA.

CONCLUSIONS: Combined detection of serum APE1-AAbs and CEACAM-1 has the advantages of high sensitivity and good accuracy in the diagnosis of colorectal cancer, and it is worthy to be popularized in clinical practice.

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