Expression of miR-146a-5p in patients with intracranial aneurysms and its association with prognosis

H.-L. Zhang, L. Li, C.-J. Cheng, X.-C. Sun

Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. sunxiaochuandn@163.com

---

• Neurology

OBJECTIVE: The study aims to detect the association of miR-146a-5p with intracranial aneurysms (IAs).

PATIENTS AND METHODS: The expression of miR-146a-5p was compared from plasma samples between 72 patients with intracranial aneurysms (IAs) and 40 healthy volunteers by quantitative Real-time polymerase chain reaction (qRT-PCR). Statistical analysis was performed to analyze the relationship between miR-146a-5p expression and clinical data and overall survival (OS) time of IAs patients. Univariate and multivariate Cox proportional hazards have also been performed.

RESULTS: Notably, higher miR-146a-5p expression was found in plasma samples from 72 patients with intracranial aneurysms (IAs) compared with 40 healthy controls. Higher miR-146a-5p expression was significantly associated with rupture and Hunt-Hess level in IAs patients. Kaplan-Meier survival analysis verified that higher miR-146a-5p expression predicted a shorter overall survival (OS) compared with lower miR-146a-5p expression in IAs patients. Univariate and multivariate Cox proportional hazards demonstrated that higher miR-146a-5p expression, rupture, and Hunt-Hess were independent risk factors of OS in patients with intracranial aneurysms (IAs).

CONCLUSIONS: MiR-146a-5p expression may serve as a biomarker for predicting prognosis in patients with IAs.

Free PDF Download