OBJECTIVE: To investigate the role and mechanism of fibroblast growth factor 23 (FGF23) in renal interstitial fibrosis. MATERIALS AND METHODS: Rat renal tubular epithelial cell line (NRK-52E) was selected for in vitro experiments. Effect of FGF23 on extracellular matrix was observed. High expression of FGF23 was induced by injecting the plasmid into the caudal vein. … Continue reading FGF23 promotes renal interstitial fibrosis by activating β-catenin