OBJECTIVE: Wnt/β-catenin pathway regulates cell proliferation and apoptosis. GSK-3β degrades β-catenin and negatively regulates Wnt/β-catenin pathway. A previous study indicated that the GSK-3β expression was significantly reduced in gastric cancer, along with the increase of miR-214 expression. Bioinformatics analysis revealed complementary binding sites between miR-214 and 3’-UTR of GSK-3β mRNA. This study investigated the regulatory … Continue reading Targeting of GSK-3β by miR-214 to facilitate gastric cancer cell proliferation and decrease of cell apoptosis