Evaluation of anti convulsant activity of aerial parts of Phyllanthus longiflorus heyne ex hook

M. Jesupillai, P. Thillai Arasu*, S. Jasemine*, P. Bharathidhasan

Department of Pharmaceutical Chemistry, Arulmigu Kalasalingam College of Pharmacy, Krishnankoil, Tamilnadu (India)

*Department of Chemistry, Kalasalingam University, Krishnankoil, Tamilnadu (India)

**Department of Pharmaceutical Chemistry, National college of Pharmacy, Mukkam, Kozhikode, Kerala (India)

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• Phytomedicine

OBJECTIVES: To evaluate anti convulsant effect of aerial parts of Phyllanthus longiflorus (PHL).

MATERIALS AND METHODS: Methanol extract of aerial parts of PHL (MPHL) was prepared by continuous hot extraction method using Soxhlet apparatus. MPHL at the doses 100, 200 and 400 mg/kg were administered to male albino mice by oral route and the activity was assessed against maximal electro shock (MES) and pentylene tetrazole (PTZ) induced seizure. Abolition of hind limb extension and onset of clonic convulsion were taken as a measure of MES and PTZ induced convulsion respectively.

RESULTS: MPHL reduced the duration of extensor phase of convulsion in MES test by 62.5% (at 400 mg/kg) and also delayed the onset of clonic phase of convulsion in PTZ test by 50.7% (at 400 mg/kg). The activity was significant (p < 0.01) and comparable to the reference drug diazepam (2 mg/kg).

CONCLUSIONS: Results suggest that aerial parts of Phyllanthus longiflorus are useful in the management of convulsion.

Corresponding Author: Muthuchellam Jesupillai, MD; e-mail: Javaharpillai@rediffmail.com

Published on: 2012/10/17

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