Research on the correlation of diabetes mellitus complicated with osteoporosis with lipid metabolism, adipokines and inflammatory factors and its regression analysis

Z. Chen, G.-H. Zhao, Y.-K. Zhang, G.-S. Shen, Y.-J. Xu, N.-W. Xu

Department of Orthopedics, Changzhou 2nd People’s Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu Province, China. coolcz2000@gmail.com

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• Metabolism

OBJECTIVE: To investigate the correlation of type 2 diabetes mellitus (DM) complicated with osteoporosis with lipid metabolism, adipokines and inflammatory factors, and to define the risk factors via the multivariate regression analysis.

PATIENTS AND METHODS: A total of 80 patients with DM admitted into our hospital from November 2015 to November 2016 were enrolled, including 40 patients complicated with osteoporosis and 40 patients not complicated with osteoporosis. The levels of blood lipid, adipokines and inflammatory factors were compared; the correlations between bone mineral density (BMD) and total cholesterol (TC), adiponectin and tumor necrosis factor-α (TNF-α) were analyzed; and multivariate Logistic regression analysis was performed for osteoporosis, hyperlipidemia, abnormal adipokine levels and body’s inflammatory response.

RESULTS: The levels of serum lipid indexes, total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C), in patients without complicating osteoporosis were significantly lower than those in patients complicated with osteoporosis. The level of high-density lipoprotein cholesterol (HDL-C) was significantly higher than that in patients complicated with osteoporosis. The levels of adipokines, adiponectin and visfatin, in patients without complicating osteoporosis were significantly lower than those in patients complicated with osteoporosis. The levels of inflammatory factors, TNF-α, interleukin-6 (IL-6) and C-reactive protein (CRP), in patients without complicating osteoporosis were significantly lower than those in patients complicated with osteoporosis. There were negative correlations between BMD and TC, adiponectin and TNF-α. Abnormal blood lipid, abnormal adipokine levels and elevated inflammatory factor levels were independent risk factors for osteoporosis.

CONCLUSIONS: Enhanced inflammatory response, abnormal blood lipid metabolism and abnormal changes in adipokines may increase the risk of osteoporosis in patients with diabetes mellitus.

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