lncRNA MEG3 inhibit proliferation and metastasis of gastric cancer via p53 signaling pathway

G.-H. Wei, X. Wang

Department of Pathology, Jinzhou Medical University, Jinzhou, Liaoning Province, China. wx300@163.com

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• Oncology

OBJECTIVE: lncRNA MEG3 has been reported as a tumor suppressor gene in many different kinds of cancer, but its role in gastric cancer has not been fully understood. Then, we would like to explore its mechanism in gastric cancer.

PATIENTS AND METHODS: We first used qRT-PCR to detect the expression of lncRNA MEG3, then CCK8 and wound healing assay were used to detect the effect of lncRNA MEG3 on gastric cancer cells. Western blot assay was used to measure the expression of p53 when lncRNA MEG3 was overexpressed.

RESULTS: lncRNA MEG3 was highly expressed in the adjacent tissue, compared to the one in gastric cancer tissue. What’s more, we also found that overexpression of lncRNA MEG3 could decrease the proliferation and metastasis of gastric cancer cells. Finally, overexpression of lncRNA MEG3 could also increase the expression of p53.

CONCLUSIONS: lncRNA MEG3 could inhibit the proliferation and metastasis of gastric cancer.

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