Increased expression of long non-coding RNA SBDSP1 correlates with poor survival in colorectal cancer
H.-B. Zhou, Q. Li, M. Liu, Y.-Q. Cao, J.-Y. Xu Department of General Surgery, Chinese PLA 456th Hospital, Jinan, Shandong, China. xuj1959nn@yeah.net
OBJECTIVE: Long non-coding RNA SBDSP1 (SBDSP1) had been reported to be increased in colorectal cancer (CRC), but its effects on prognosis were still unclear. The aim of this study was to investigate the clinical significance and prognostic value of the SBDSP1 expression in CRC.
PATIENTS AND METHODS: The expression levels of SBDSP1 in CRC tissues and adjacent normal tissues were detected using quantitative Real-time PCR (qRT-PCR). The association between SBDSP1 expression and clinicopathological factors as well as survival rates were analyzed. To determine the prognostic value of SBDSP1, univariate and multivariate analysis were performed using the Cox proportional hazard analysis.
RESULTS: The relative expression levels of SBDSP1 were significantly higher in CRC tissues than in the matched normal colon tissues (p < 0.01). SBDSP1 expression was significantly associated with differentiation (p = 0.002), depth of invasion (p = 0.007) and TNM stage (p= 0.004). Additionally, patients with higher SBDSP1 expression have significantly shorter disease-free survival (p = 0.006) and overall survival (p = 0.001) compared to those with lower expression. Moreover, univariate and multivariate analysis identified high SBDSP1 expression as an unfavorable prognostic factor for both overall survival and disease-free survival.
CONCLUSIONS: The present study provides the first evidence that SBDSP1 may be a useful indicator of prognosis in patients with CRC.
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To cite this article
H.-B. Zhou, Q. Li, M. Liu, Y.-Q. Cao, J.-Y. Xu
Increased expression of long non-coding RNA SBDSP1 correlates with poor survival in colorectal cancer
Eur Rev Med Pharmacol Sci
Year: 2017
Vol. 21 - N. 17
Pages: 3837-3841